Roger J Griffin Selected Research

2- benzyl- 3- (4- chlorophenyl)- 3- (3- hydroxypropoxy)- 2,3- dihydroisoindol- 1- one

10/2006

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.

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Roger J Griffin Research Topics

Disease

20	Neoplasms (Cancer) 12/2022 - 10/2002
2	Colorectal Neoplasms (Colorectal Cancer) 01/2016 - 05/2004
2	Melanoma (Melanoma, Malignant) 01/2016 - 08/2012
2	Colonic Neoplasms (Colon Cancer) 08/2012 - 05/2006
2	Sarcoma (Soft Tissue Sarcoma) 10/2006 - 03/2005
1	Osteosarcoma (Osteogenic Sarcoma) 01/2021
1	Liver Neoplasms (Liver Cancer) 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2016
1	Urinary Bladder Neoplasms (Bladder Cancer) 10/2013
1	Prostatic Neoplasms (Prostate Cancer) 01/2012
1	Disease Progression 06/2008
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/2008
1	Ataxia Telangiectasia (Louis Bar Syndrome) 04/2007
1	Carcinoma (Carcinomatosis) 09/2005
1	Ovarian Neoplasms (Ovarian Cancer) 09/2005
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2005

Drug/Important Bio-Agent (IBA)

8	Phosphotransferases (Kinase)IBA 12/2022 - 04/2007
7	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 05/2004
4	Pharmaceutical PreparationsIBA 01/2020 - 08/2012
3	EnzymesIBA 06/2020 - 01/2012
3	DNA-Activated Protein KinaseIBA 01/2020 - 04/2007
3	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2020 - 06/2008
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2012
2	LigandsIBA 01/2021 - 10/2013
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2016 - 09/2012
2	Pyrimethamine (Daraprim)FDA Link 01/2016 - 08/2012
2	Cisplatin (Platino)FDA LinkGeneric 08/2012 - 01/2005
2	Temozolomide (Temodar)FDA LinkGeneric 08/2012 - 05/2004
2	Folic Acid AntagonistsIBA 08/2012 - 07/2009
2	Etoposide (VP 16)FDA LinkGeneric 08/2012 - 05/2006
2	Caspase 9IBA 01/2012 - 09/2005
2	Caspase 3 (Caspase-3)IBA 01/2012 - 09/2005
2	3- (4- chlorophenyl)- 3- (4- hydroxy- 3,5- dimethoxybenzyloxy)- 2- propyl- 2,3- dihydroisoindol- 1- oneIBA 10/2006 - 03/2005
1	Mitogen-Activated Protein KinasesIBA 12/2022
1	Protein Kinases (Protein Kinase)IBA 06/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020
1	Topoisomerase InhibitorsIBA 01/2020
1	Antineoplastic Agents (Antineoplastics)IBA 01/2016
1	Antimalarials (Antimalarial Agents)IBA 01/2016
1	MTOR InhibitorsIBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	methylbenzoprimIBA 01/2016
1	Cysteine (L-Cysteine)FDA Link 01/2014
1	benzimidazoleIBA 10/2013
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2013
1	OxadiazolesIBA 10/2013
1	trans-sodium crocetinate (crocetin)IBA 10/2013
1	Glucose (Dextrose)FDA LinkGeneric 08/2012
1	Deoxyglucose (2 Deoxy D glucose)IBA 08/2012
1	StaurosporineIBA 08/2012
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 08/2012
1	2- (4- ethylpiperazin- 1- yl)- N- (4- (2- morpholino- 4- oxo- 4H- chromen- 8- yl)dibenzo(b,d)thiophen- 1- yl)acetamideIBA 08/2012
1	1,2-bis(isothiazol-5-yl)disulfaneIBA 01/2012
1	Lysine (L-Lysine)FDA Link 01/2012
1	Androgen Receptors (Androgen Receptor)IBA 01/2012
1	Histones (Histone)IBA 01/2012
1	ProdrugsIBA 09/2011
1	NU6102IBA 09/2011
1	Cyclin-Dependent Kinase 2IBA 09/2011
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2010
1	Pemetrexed (MTA)FDA Link 07/2009
1	NU 3153IBA 07/2009
1	ThymidineIBA 07/2009
1	Indicators and Reagents (Reagents)IBA 06/2008
1	2- benzyl- 3- (4- chlorophenyl)- 3- (3- hydroxypropoxy)- 2,3- dihydroisoindol- 1- oneIBA 10/2006
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 05/2006
1	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- oneIBA 05/2006
1	Therapeutic UsesIBA 05/2006
1	PoisonsIBA 05/2006
1	Paclitaxel (Taxol)FDA LinkGeneric 09/2005
1	SurvivinIBA 09/2005
1	6- ((3- chloro)anilino)- 2- (isopropyl- 2- hydroxyethylamino)- 9- isopropylpurineIBA 09/2005
1	4- (6- cyclohexylmethoxy- 9H- purin- 2- ylamino)- N,N- diethylbenzamideIBA 09/2005
1	Cytotoxins (Cytolysins)IBA 11/2002
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2002

Therapy/Procedure

5	Therapeutics 03/2017 - 09/2005
1	Oral Administration 01/2021
1	Drug Therapy (Chemotherapy) 01/2020
1	Radiotherapy 01/2020
1	Heterologous Transplantation (Xenotransplantation) 01/2016